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Rhogam shot9/10/2023 ![]() ![]() ![]() To identify the exact antigens targeted by the mothers’ antibodies, Van de Water and her colleagues conducted the research in Northern California using blood samples from 246 mothers of children with autism and of a control group of 149 mothers of children without autism to examine their reactivity with the candidate antigens. “We hope that, one day, we can tell a mother more precisely what her antibody profile means for her child, then target interventions more effectively.” “Now we will be able to better determine the role of each protein in brain development,” said Van de Water, professor of internal medicine. Earlier studies by Van de Water and her colleagues found that women with certain antibodies in their bloodstreams are at greater risk of having a child with autism and that their children exhibited more severe language delays, irritability and self-injurious behaviors than did the autistic children of mothers whose blood did not have the antibodies. The study was led by principal investigator and immunologist Judy Van de Water, a researcher affiliated with the MIND Institute. The research, “ Autism-specific maternal autoantibodies recognize critical proteins in developing brain,” is published online today in Translational Psychiatry, a Nature journal. UC Davis MIND Institute Professor Judy Van de Water discusses her research discovery that approximately 23 percent of all cases of autism are related to maternal antibodies attacking the fetal brain. In fact, specific combinations of MAR antibodies were not found in the blood of mothers whose children were typically developing. ![]() The study found that the mothers of children with autism were more than 21 times as likely to have the specific MAR antibodies in their systems that reacted with fetal brain proteins, or antigens, than were the mothers of children who did not have autism. The researchers have named autism related to these antibodies “Maternal Autoantibody-Related,” or MAR autism. The finding is the first to pinpoint a specific risk factor for a significant subset of autism cases, as well as a biomarker for drug development and early diagnosis. UC Davis MIND Institute researchers have identified the specific antibodies that target fetal brain proteins in the blood of a subset of women whose children are diagnosed with autism. In a newly published study, researchers from UC Davis identify a biomarker for autism in a subset of children, finding that the mothers of children with autism were more than 21 times as likely to have the specific MAR antibodies in their systems that reacted with fetal brain proteins, or antigens, than were the mothers of children who did not have autism. ![]()
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